CIÊNCIA & PESQUISA
Publicações & Impacto
Nossa produção científica é guiada pelo rigor metodológico e pelo compromisso com a saúde coletiva estrutural.
Nossa produção científica é guiada pelo rigor metodológico e pelo compromisso com a saúde coletiva estrutural.
IRPP & Pesquisadores Associados
Suicide is a leading cause of adolescent mortality worldwide. Exogenous poisoning—defined as exposure to toxic substances such as medications or chemicals— is a common method, but large-scale epidemiological data in Brazil are limited. This study describes sociodemographic profiles, temporal trends, regional disparities, and the COVID-19 pandemic’s impact on adolescent suicide attempts by exogenous poisoning in Brazil from 2018 to 2023. We conducted a study, the SINAN database, on reported suicide attempts by exogenous poisoning in adolescents aged 10–19 years nationwide.
IRPP & Pesquisadores Associados
Tuberculosis preventive therapy (TPT) is critical in interrupting progression to disease, transmission and reducing incidence rates. We analysed surveillance data on 171 174 individuals initiating TPT from January 2019 to December 2024. In Brazil, large-scale implementation of a patient-friendly short-course regimen (3HP) was effective and likely cost-saving for a resource-strained public health system. Our evaluation provides robust, real-world evidence that implementing this regimen improved TPT coverage and completion nationwide while reducing costs and TB disease burden.
IRPP & Pesquisadores Associados
Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, a transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. We found that BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion in Mtb-infected mice increased glutathione levels and Gpx4 expression that inhibit lipid peroxidation. Bach1−/− macrophages exhibited increased resistance to Mtb-induced cell death, while Mtb-infected Bach1-deficient mice displayed reduced bacterial loads, pulmonary necrosis and lipid peroxidation concurrent with increased survival.